Journal: Nature Communications

Article Title: Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design

doi: 10.1038/s41467-023-40191-3

Figure Lengend Snippet: a – c Images of Masson’s trichrome staining for immune responses to three types of model devices after 4-week subcutaneous implantation in mice: an ultrasoft device with a soft interlayer (i.e., SEBS/hydrogel bilayer with the thicknesses of 1.2 μm and 200 μm, respectively), a SEBS device, and a hydrogel device (both in the thickness of 200 μm for the latter two). Implants labeled with #; scale bar, 200 μm. d Measured scar tissue thicknesses from the Masson’s Trichrome staining images for the three cases. Data for scar tissue thickness are represented as mean values ± standard deviation (s.d.) from five samples, and the corresponding data points are overlaid. (statistical significance was analyzed via two-tailed T test, *** P = 0.00032; n.s., not significant). e Schematics showing an ultrasoft EP-record device attached to a rat heart for measuring ECG signals. f Pictures showing an ultrasoft device wrapping on a beating heart without visible location shift during a period of 5 minutes recording (top). In comparison, an EP device built on a SEBS substrate is observed with some rotation and upward shifting (bottom) (scale bar, 5 mm). g ECG signals recorded by an ultrasoft device (top) and a conventional SEBS device (bottom). The maintained recording location of the ultrasoft device on the heart is also reflected by the consistency of the signal features across the 5-min period, which is very different that those from the conventional device. h Left ventricle pressure (LVP) recorded when the devices are wrapped on the heart: stable LVP is maintained before and after mounting the ultrasoft device (top), whereas a conventional device with higher mechanical constraint to the heart beating induced an obvious increase in the LVP amplitude (bottom).

Article Snippet: For the ECG measurement on the human skin surface, the electrodes are connected to a commercial ECG measurement kit (Backyard Brains).

Techniques: Staining, Labeling, Standard Deviation, Two Tailed Test, Comparison

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: Visual representation of the study protocol. Study drugs were taken on protocol days 1–10. ECGs, mid-nasal viral swabs, symptom surveys, and vital signs were self-collected on protocol days 1–14, while only ECGs, symptom surveys, and vital signs were obtained on days 21 and 28. On days 2, 4, 9, 14, and 28, planned investigator-initiated contact was undertaken to collect subjective data and encourage adherence. Vital signs were collected twice daily. ECGs were uploaded to the secure web portal where study coordinators pushed them to the core ECG laboratory and then recorded the returned interpretation, as described in the “Methods” section. Viral swabs were sent to the core virology laboratory. All data were warehoused in REDCap .

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques:

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: Six-lead electrocardiogram acquisition by the patient using the AliveCor® KardiaMobile 6L device ( A ). Note: rotating the device 180° results in limb lead reversal. Implementation of remote QTc monitoring ( B ). ECG is collected by the participant, uploaded to a secure web portal, and transmitted by study coordinators for adjudication at a core laboratory. QTc results are transmitted to study coordinators for safety ascertainment by study clinicians.

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques:

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: Characteristics of per-participant ECG collection.

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques: Standard Deviation

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: Red bars represent days that were specified for ECG submission in the protocol, while gray bars represent days when ECG upload was not required.

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques:

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: ECG protocol adherence was noted to reduce to <70% after the study drugs were discontinued after day 14.

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques:

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: Average ECG protocol adherence (proportion of expected study days with ECG) stratified by demographic characteristics.

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques:

Journal: Communications Medicine

Article Title: Implementation of a fully remote randomized clinical trial with cardiac monitoring

doi: 10.1038/s43856-021-00052-w

Figure Lengend Snippet: Patient-level adverse events related to QTc prolongation.

Article Snippet: A courier delivered study drugs, a self-monitoring kit including a six-lead ECG monitor (Fig. ; KardiaMobile 6L, AliveCor®, Mountain View, CA), an oxygen saturation (SpO ) monitor (Vive Precision), and an oral thermometer (Adtemp IV), as well as mid-nasal swabs for SARS-CoV-2 RT-PCR testing to each participant.

Techniques: